Clinical Study

Transdermal Patch Delivery of Vitamin B12 as an Alzheimer’s Treatment Method

Study Duration

8 Weeks

Study Type

In Vitro

Summary

A transdermal drug delivery system (nanofiber patches) was designed with donepzeil (DO) and vitamin B12 to remove the bioavailability limitation of DO and B12. Both compounds are effective in AD-related pathologies and offer combination therapy, targeting effective treatment with a prolonged release.

This was a lab-based study conducted on cell cultures (SH-SY5Y neuroblastoma cells).

Key Findings

• A nanofiber patch system is structurally stable and suitable for transdermal use
• The system showed rapid release on the first day, followed by sustained release for 14 days
• Increased viability & reduced Alzheimer’s-related damage in cells
• Treated cells looked healthier vs. untreated Alzheimer’s model cells

Conclusion

Hydrophilic (water-loving) drugs can be effectively delivered through the skin with the high surface area/volume ratio of the fibers. Transdermal drug delivery systems are a conceivable option to overcome the difficulties experienced in oral drug use in Alzheimer's patients.